Jessie is one of the members of Team Rocket, literally Rocket Gang or Rocket Brigade. It is the first syndicate to be revealed in the Pokémon metaseries. In each of its various incarnations, Team Rocket desires to steal Pokémon to further its goal of world domination. They are led by the criminal mastermind, Giovanni. After debuting in the original games, Red and Blue, the syndicate then appeared in the animated series and the Pokémon Trading Card Game. They also appear in the Yellow, Gold, Silver, Crystal, FireRed, and LeafGreen versions.
Jessie is a loudmouth who often abuses the other two. She grew up in a poor foster family, while her mother focused on missions from Team Rocket. Before she joined Team Rocket, she aspired to be a nurse; however, the school that she wanted to attend wouldn't accept her application. Undeterred, she attempted to attend a nursing school for Pokémon. There, she befriended a sweet but clumsy Chansey who seemed to be the only Pokémon in the school willing to be her friend. Jessie ended up failing her classes and being unable to become a Pokémon nurse, declining her friend's offer to give her its own nurse cap. From there, she moved on to Pokémon Tech, a private school. This is most likely where she first met James. They flunked out of the school together before joining a biking gang, and then Team Rocket. She is voiced by Megumi Hayashibara (and was replaced on an interim basis by Akiko Hiramatsu when Hayashibara was on maternity leave) in the Japanese version, Rachel Lillis during the first eight seasons of the English anime and Michele Knotz from the ninth season onwards.